| Modification Notes |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZFOC1, also known as ZNF644 (zinc finger protein 644), ZEP2 (zinc finger motif enhancer-binding protein 2) or BM-005, is a 1,327 amino acid nuclear protein belonging to the Krüeppel C2H2-type zinc-finger protein family. Existing as three alternatively spliced isoforms, ZFOC is involved in transcriptional regulation and contains seven C2H2-type zinc fingers. The gene encoding ZFOC1 maps to human chromosome 12q24.31. |