| Product Name | SPBP Antibody (N-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the N-terminus of SPBP of human origin |
| Modification Notes | SPBP (SPRE-binding protein), also known as AR1 or TCF20 (transcription factor 20), is a 1,960 amino acid nuclear protein that is expressed in most tissues, with the exception of ovary and prostate. Two isoforms of SPBP exists due to alternative splicing events. While SPBP isoform 1 is predominantly expressed in liver and kidney, with exclusive expression in brain, heart and testis, SPBP isoform 2 is predominantly expressed in lung. Considered a transcriptional activator, SPBP binds to the regulatory region of MMP-3 thereby controling stromelysin expression. SPBP exists as a homodimer that interacts with RNF4 and c-Jun. SPBP stimulates the activity of several transcriptional activators such as Sp1, Pax-6 and Ets-1, suggesting a function as a coactivator. SPBP contains an A.T. hook DNA-binding domain and a PHD-type zinc finger, and is phosphorylated upon DNA damage by ATM or ATR. It is suggested that SPBP is a phosphoserine-specific repressor of ERå (estrogen receptor alpha). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of SPBP of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the N-terminus of SPBP of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the N-terminus of SPBP of human origin |
| Entrez Gene | 6942 |
|---|
| Application Notes | recommended for detection of SPBP of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
