| Modification Notes |
Thioredoxins comprise a family of small proteins that, by catalyzing the oxidation of disulfide bonds, participate in redox reactions throughout the cell. TMX3 (thioredoxin-related transmembrane protein 3), also known as thioredoxin domain-containing protein 10, protein disulfide-isomerase TMX3, PDIA13 or TXNDC10, is a 454 amino acid single-pass endoplasmic reticulum membrane protein that belongs to the protein disulfide isomerase family. Existing as two alternatively spliced isoforms and containing one thioredoxin domain, TMX3 likely functions as a dithiol oxidase and disulfide isomerase, which plays a role in protein folding by catalyzing disulfide bond rearrangement. Widely expressed, TMX3 is found at highest levels in eye, placenta, muscle, brain, testis, lung, uterus, kidney, stomach, prostate, bone, liver and brain, and is encoded by a gene located on human chromosome 18. |