| Product Name | Integrin βL1 Antibody (N-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of Integrin βL1 of human origin |
| Modification Notes | Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ∫L1 (integrin, beta-like 1), also known as OSCP (osteoblast-specific cysteine-rich protein), TIED (ten integrin EGF-like repeat domain-containing protein) or ITGBL1, is a 494 amino acid secreted protein that is widely expressed in many tissues, but readily detectable only in aorta. Integrin ∫L1 contains ten tandem EGF-like repeats that are similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Integrin βL1 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other integrin family members also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of Integrin &beta L1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of Integrin βL1 of human origin |
| Entrez Gene | 9358 |
|---|
| Application Notes | recommended for detection of Integrin βL1 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other integrin family members also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
