Application
Western blot analysis of untreated (A) and CaMKII-treated (B) rat recombinant TPH2.| Product Name | p-TPH2 Antibody (Ser 19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Ser 19 phosphorylated TPH2 of mouse, rat and zebrafish origin by WB and IP; also reactive with additional species, including bovine |
| Modification | Phosphoralated |
| Modification Notes | Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and tryptophan hydroxylase 2 (TPH2) comprise a small family of monooxygenases that catalyze the rate-limiting step in the catabolism of aromatic L-amino acids and utilize tetrahydropterine as a cofactor. TPH2 is highly expressed in the central nervous system (CNS), mainly in the brain. TPH2 catalyzes the first step in the biosynthesis of serotonin in the CNS and melatonin in the pineal gland, and may be involved in the pathology of several neuropsychiatric disorders. Glucocorticoid-mediated reduction of TPH2 is associated with the etiology of mood disorders, specifically psychotic major depression, and TPH2 may be related to dysregulation of serotonin neurotransmission in the brain which commonly leads to suicidal behavior. Mouse and rat TPH2 are phosphorylated on Ser 19. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIP |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Ser 19 phosphorylated TPH2 of mouse rat and zebrafish origin by WB and IP also reactive with additional species including bovine |
|---|---|
| Tissue Specificity | recommended for detection of Ser 19 phosphorylated TPH2 of mouse, rat and zebrafish origin by WB and IP; also reactive with additional species, including bovine |
| Entrez Gene | 216343 |
|---|
Application
Western blot analysis of untreated (A) and CaMKII-treated (B) rat recombinant TPH2.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
