| Modification Notes |
The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTC (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG6 (Conserved oligomeric Golgi complex component 6), also known as COD2, is a 657 amino acid component of the COG complex. Expressed in brain and ovary, COG6 is a peripheral membrane protein that is essential for the proper function of the Golgi, namely maintaining Golgi structure and mediating vesicle docking and fusion. Three isoforms of COG6 exist due to alternative splicing events. |