UXT (Ubiquitously expressed transcript protein), also known as ART-27 (Androgen receptor trapped clone 27 protein), is a 157 amino acid protein that is found in the nucleus, cytoplasm, cytoskeleton and centrosome. Expressed ubiquitously, UTX is found at the highest levels in the heart, kidney, liver, adrenal gland, skeletal muscle, peripheral blood leukocytes, lymph node and pancreas. The primay function of UXT is to interact with the N-terminus of the androgen receptor and facilitate receptor-induced transcriptional activation. UXT is also thought to be a component of LRP130, a multidomain organizer that integrates cytoskeletal networks with vesicular trafficking, chromosome remodeling, transcription and cytokinesis. Furthermore, the overexpression of UXT in a number of tumor tissues has suggested that UXT plays a role in tumorigenesis.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of UXT of human and canine origin by WB, IP and ELISA: