Application
Western blot analysis of CREB3L2 expression in HeLa (A) and THP-1 (B) nuclear extracts.Application
Western blot analysis of CREB3L2 expression in Jurkat whole cell lysate.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.| Product Name | CREB3L2 Antibody (F-23) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of CREB3L2 of human origin by WB, IP, IF, IHC(P) and ELISA |
| Modification Notes | CREB3L2 (cAMP responsive element binding protein 3-like 2), also known as BBF2H7, is a 520 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum and contains one bZIP domain. Expressed in a wide variety of tissues, including lung, spleen, placenta and intestine, CREB3L2 functions as a transcriptional activator that binds DNA as a dimer and is thought to act during endoplasmic reticulum stress, specifically by activating the transcription of unfolded protein response target genes. Additionally, CREB3L2 is thought to be involved in preventing the accumulation of unfolded proteins in damaged neurons, thereby playing a role in neuronal maintenance. Chromosomal rearrangements that involve the CREB3L2 gene are associated with low grade fibromyxoid sarcomas (LGFMSs). Multiple isoforms of CREB3L2 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| WB:1:500~1:2000 IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of CREB3L2 of human origin by WB IP IF IHC(P) and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of CREB3L2 of human origin by WB, IP, IF, IHC(P) and ELISA |
| Entrez Gene | 64764 |
|---|
Application
Western blot analysis of CREB3L2 expression in HeLa (A) and THP-1 (B) nuclear extracts.
Application
Western blot analysis of CREB3L2 expression in Jurkat whole cell lysate.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
