Application
Western blot analysis of PTPMT1 expression in K-562 (A), Ramos (B), MCF7 (C) and HISM (D) whole cell lysates.| Product Name | PTPMT1 Antibody (H-41) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 87-127 mapping within an internal region of PTPMT1 of human origin |
| Modification Notes | Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPå, PTP∫, PTP©, PTP∂, PTPe, PTPΩ, PTP˚ and PTPµ. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTPMT1 (protein tyrosine phosphatase mitochondrial 1), also known as MOSP or PLIP (phosphoinositide lipid phosphatase) and previously known as DUSP23, is a widely expressed PTP membrane protein with high expression levels in pancreatic ∫ cells. PTPMT1 exclusively localizes to the matrix face of the inner membrane of the mitochondrion. It is responsible for dephosphorylating mitochondrial proteins and therefore plays a significant role in the production of ATP and secretion of insulin. For its substrate, PTPMT1 displays a specific preference for the lipid signaling molecule, phosphatidylinositol 5-phosphate (PI(5)P). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PTPMT1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 87-127 mapping within an internal region of PTPMT1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 87-127 mapping within an internal region of PTPMT1 of human origin |
| Entrez Gene | 114971 |
|---|
Application
Western blot analysis of PTPMT1 expression in K-562 (A), Ramos (B), MCF7 (C) and HISM (D) whole cell lysates.| Application Notes | recommended for detection of PTPMT1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
