| Product Name | Tβ-10 Antibody (FL-44) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-44 representing full length Tβ-10 of human origin |
| Modification Notes | Thymosin ∫-10 (T∫-10) is a member of the highly conserved ∫-thymosin family. It is a monomeric G-Actin sequestering protein of the cytoplasm that regulates Actin dynamics. T∫-10 consists of 43 amino acids and often forms å-helical structures. T∫-10 has been shown to act as an Actin-mediated tumor suppressor. Overexpression of this protein inhibits endothelial cell proliferation, migration, invasion and tube formation. In human ovarian cancer cells, T∫-10 also increases apoptosis frequency. T∫-10 directly interacts with Ras, resulting in inhibition of the Ras downstream signaling pathways which, in turn, exhibits a negative effect on angiogenesis and tumor growth. More specifically, this inhibitive effect might be mediated by the downregulation of vascular endothelial growth factor (VEGF), VEGF receptor-1 (VEGFR-1) and Integrin åV, which suggests a role for T∫-10 in anticancer therapy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Tβ-10 and to a lesser extent Tβ-4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-44 representing full length T&beta -10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-44 representing full length Tβ-10 of human origin |
| Entrez Gene | 9168 |
|---|
| Application Notes | recommended for detection of Tβ-10 and to a lesser extent Tβ-4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
