| Product Name | robo3 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 696-765 mapping within an N-terminal extracellular domain of robo3 of human origin |
| Modification Notes | Secreted leucine-rich repeat-containing proteins 1-3 (Slit1-3) are secreted glycoproteins that influence axonal guidance and mediate normal neural progression by acting as high-affinity signaling ligands for the repulsive guidance receptors, robo 1 and robo 2 (also designated Roundabout 1 and 2). Within the developing CNS of different vertebrate systems, Slit proteins are expressed in equivalent regions, suggesting there is a conservation of function for vertebrate homologs. Robo3 plays a crucial role in controlling axon guidance at the midline of the CNS. Two human robo3 isoforms, robo3A and robo3B, which differ by the insertion of 26 amino acids at the N-terminus, appear to be evolutionary conserved. Robo3 guides commissural axons by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through robo1. Together, the robo proteins prescribe developmental paths during neural development. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of robo3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 696-765 mapping within an N-terminal extracellular domain of robo3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 696-765 mapping within an N-terminal extracellular domain of robo3 of human origin |
| Entrez Gene | 64221 |
|---|
| Application Notes | recommended for detection of robo3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
