| Product Name | ChoK Antibody (H-210) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 91-300 mapping within an internal region of ChoKα of human origin |
| Modification Notes | The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway (1). Choline kinase, the initial enzyme in the sequence, playss a role in cell growth proliferation (1). Hemicholinium-3 (HC-3), an inhibitor for Choline Kinase (also known as ChoK and CKI), drastically reduces entry into S phase after stimulation by growth factors (1-3). In ras-transformed cells, an increased level of phosphorylcholine (PCho) results from the consecutive activation of phospholipase D (PLD) and ChoK (3-5). ChoK and its product, PCho, have been implicated in human carcinogenesis, including the development of human breast cancer, and ChoK dysregulation is found in a variety of human tumors such as lung, colorectal, and prostate tumors (6,7). The human Choline kinase gene maps to chromosome 11q13.2 (1). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ChoKα isoforms 1,2, and to a lesser extent, ChoKβ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 91-300 mapping within an internal region of ChoK&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 91-300 mapping within an internal region of ChoKα of human origin |
| Entrez Gene | 1119 |
|---|
| Application Notes | recommended for detection of ChoKα isoforms 1,2, and to a lesser extent, ChoKβ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
