| Modification Notes |
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR149 (G protein-coupled receptor 149), also known as PGR10 or IEDA, is a 731 amino acid multi-pass membrane protein that functions as an orphan receptor and belongs to the G protein-coupled receptor family. The gene encoding GPR149 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. |