Application
Western blot analysis of mucolipin 1 expression in non-transfected: (A) and human mucolipin 1 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of mucolipin 1 expression in non-transfected: (A) and human mucolipin 1 transfected: (B) 293T whole cell lysates.| Product Name | mucolipin 1 Antibody (H-75) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 106-180 mapping within an internal region of mucolipin 1 of human origin |
| Modification Notes | The gene encoding human mucolipin 1 maps to chromosome 19p13.3-p13.2 (1). Mutations in this gene cause a rare, autosomal recessive lysosomal storage disease known as mucolipidosis type IV (MLIV) (1). Clinical characteristics of MLIV include psychomotor retardation, retinal degeneration, corneal opacities and strabismus (2). Mucolipin 1 localizes to the plasma membrane and contains six transmembrane domains (3,4). The carboxy terminus of mucolipin 1 shares sequence homology with polycystin-2 and the transient receptor potential cation channel family (3,4). The concentration of intracellular Ca(2+) regulates the permeability of mucolipin 1 to Ca(2+), Na(+) and K(+) (5). The influence of Ca(2+) on mucolipin 1 represents a possible role for mucolipin 1 in lysosomal exocytosis and the trafficking of late endosomes and lysosmes (5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of mucolipin 1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 106-180 mapping within an internal region of mucolipin 1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 106-180 mapping within an internal region of mucolipin 1 of human origin |
| Entrez Gene | 57192 |
|---|
Application
Western blot analysis of mucolipin 1 expression in non-transfected: (A) and human mucolipin 1 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of mucolipin 1 expression in non-transfected: (A) and human mucolipin 1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of mucolipin 1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
