| Product Name | p-SGK3 Antibody (Ser 486) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Ser 486 of SGK3 of human origin |
| Modification | Phosphoralated |
| Modification Notes | Serum- and glucocorticoid-regulated kinase (SGK), a serine/threonine protein kinase, is transcriptionally regulated by serum, glucorticoids and mineralocorticoids. SGK regulates the control of extracellular fluid volume, blood pressure and sodium homeostasis and is also a component of the p38 MAPK-mediated response to hyperosmotic stress. SGK is a downstream target of phosphoinositide 3-kinase (PI 3-kinase)-stimulated growth factor signaling, and 3-phosphoinositide-dependent protein kinase 1 (PDK1) is capable of phosphorylating the activation-loop of SGK at Thr 256. Thr 256 and Ser 422 are the putative phosphorylation sites of SGK. Mutations at those putative phosphorylation sites inhibit SGK activation. For example, the Ser 422 to Ala mutant, lacking a PDK-2 phosphorylation site, is inactive and resistant to activation by Insulin. Thus, in addition to regulation at the level of gene expression, the enzymatic activity of SGK is regulated by multiple protein kinases, including PKA, PDK1, and PDK2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Ser 486 phosphorylated SGK3 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Ser 486 of SGK3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Ser 486 of SGK3 of human origin |
| Entrez Gene | 23678 |
|---|
| Application Notes | recommended for detection of Ser 486 phosphorylated SGK3 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
