| Modification Notes |
CTP synthetase catalyses the conversion of uridine 5'-triphosphate to cytidine 5'-triphosphate, the last step of the pyrimidine biosynthetic pathway. The CTP synthetase protein sequence shows a strong degree of homology with bacterial and human CTP synthetases. An alternative pathway for CTP synthesis may exist in yeast, which could involve either a divergent duplicated gene or a different route beginning with the amination of uridine mono- or diphosphate. Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in yeast. |