Application
Western blot analysis of mucolipin 3 expression in Hep G2 whole cell lysate.| Product Name | mucolipin 3 Antibody (H-60) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 176-235 mapping within an internal region of mucolipin 3 of human origin |
| Modification Notes | The mucolipins are a family of cation channel proteins designated mucolipin 1, mucolipin 2 and mucolipin 3. Mucolipins are predominantly expressed within the endocytic pathway and may regulate membrane traffic and/or degradation. Mucolipin 3, also known as TRPML3, TRP-ML3 or MCOLN3, is a 553 amino acid multi-pass membrane protein that belongs to the Polycystin family of transient receptors and localizes to lysosomes. Also expressed in hair celsl, mucolipin 3 may play a critical role at the ankle-link region during hair-bundle growth. Mutations in mucolipin 3 have been linked to hair cell degeneration leading to hearing loss and balance disorders. Defects in mucolipin 3 may be associated with mucolipidosis type IV, an autosomal recessive lysosomal storage disorder that causes severe neurodegeneration, achlorhydria and visual impairments. Two isoforms exists due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of mucolipin 3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 176-235 mapping within an internal region of mucolipin 3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 176-235 mapping within an internal region of mucolipin 3 of human origin |
| Entrez Gene | 55283 |
|---|
Application
Western blot analysis of mucolipin 3 expression in Hep G2 whole cell lysate.| Application Notes | recommended for detection of mucolipin 3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
