| Product Name | EPCR Antibody (FL-238) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-238 representing full length EPCR of human origin |
| Modification Notes | Thrombomodulin (TM) is an endothelial specific receptor that forms a complex with Thrombin, a protein with procoagulant, inflammatory and anticoagu-lant effects. The TM/Thrombin complex activates Protein C (PC) to generate activated Protein C (APC) and initiate the APC anticoagulant pathway. APC attenuates Thrombin formation through the inactivation, by limited proteolysis, of two significant cofactors of blood clot formation, Factor Va and Factor VIIIa. This process is augmented by the activity of the endothelial cell Protein C receptor (EPCR), which binds both PC and APC with high affinity. The EPCR gene maps to human chromosome 20q11.2 and encodes an anticoagulant that is preferentially expressed on large blood vessel endothelium in the heart and lung with some expression in capillaries in the lung and skin. EPCR, also designated CCD41 in mouse, is a member of the major histocompatibility complex and displays significant homology to CD1. Soluble plasma EPCR is thought to inhibit the membrane-bound EPCR activation of the APC pathway. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of EPCR of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-238 representing full length EPCR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-238 representing full length EPCR of human origin |
| Entrez Gene | 10544 |
|---|
| Application Notes | recommended for detection of EPCR of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
