| Product Name | MiRP1 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-70 mapping at the N-terminus of MiRP1 of human origin |
| Modification Notes | Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. KCNE1 and KCNE2 (also known as MiRP1) are two single transmembrane domain b subunits of the delayed rectifier potassium channel IKr. In cardiac tissue, MiRP1 assembles with HERG, the pore-forming a subunit of IKr. In the brain, MiRP1 associates with KCNQ2 and accelerates the dissociation of KCNQ2 from the KCNQ2-KCNQ3 complex. MiRP1 also regulates the current amplitude and gating properties of the KCNQ1 K+ channel, and may assemble with KCNQ1 in the stomach to aid in K+ recycling, which is necessary for gastric acid secretion. The gene encoding human MiRP1 maps to chromosome 21q22.12. Missense mutations in the gene for MiRP1 result in congenital long QT syndrome and drug-induced cardiac arrhythmia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MiRP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-70 mapping at the N-terminus of MiRP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-70 mapping at the N-terminus of MiRP1 of human origin |
| Entrez Gene | 9992 |
|---|
| Application Notes | recommended for detection of MiRP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
