Application
Western blot analysis of C17orf66 expression in non-transfected: (A) and human C17orf66 transfected: (B) 293T whole cell lysates.| Product Name | C17orf66 Antibody (P-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of C17orf66 of human origin |
| Modification Notes | C17orf66 (chromosome 17 open reading frame 66) is a 570 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of C17orf66 of human origin by WB, IP, IF and ELISA non cross-reactive with other C17orf family members also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of C17orf66 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of C17orf66 of human origin |
| Entrez Gene | 256957 |
|---|
Application
Western blot analysis of C17orf66 expression in non-transfected: (A) and human C17orf66 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of C17orf66 of human origin by WB, IP, IF and ELISA non cross-reactive with other C17orf family members also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
