Application
Western blot analysis of BTN3A3 expression in non-transfected: (A) and human BTN3A3 transfected: (B) 293T whole cell lysates.| Product Name | BTN3A3 Antibody (C-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within a C-terminal cytoplasmic domain of BTN3A3 of human origin |
| Modification Notes | BTN3A3 (butyrophilin subfamily 3 member A3), also known as BTF3, is a 584 amino acid protein belonging to the immunoglobulin superfamily and the BTN/MOG family. As a single-pass type I membrane protein, BTN3A3 contains one B30.2/SPRY domain and two Ig-like V-type (immunoglobulin-like) domains. The gene that encodes BTN3A3 maps to human chromosome 6, which contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BTN3A3 of human origin by WB, IP, IF and ELISA non cross-reactive with BTN3A1 or BTN3A2: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within a C-terminal cytoplasmic domain of BTN3A3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within a C-terminal cytoplasmic domain of BTN3A3 of human origin |
| Entrez Gene | 10384 |
|---|
Application
Western blot analysis of BTN3A3 expression in non-transfected: (A) and human BTN3A3 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of BTN3A3 of human origin by WB, IP, IF and ELISA non cross-reactive with BTN3A1 or BTN3A2: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
