| Product Name | FOXN4 Antibody (H-195) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-195 mapping at the N-terminus of FOXN4 of human origin |
| Modification Notes | The human gene FOXN4 encodes for a 476 amino acid nuclear protein designated FOXN4. FOXN4 cooperates with key retinogenic factors to mediate the multipotent differentiation of retinal progenitors and is believed to regulate neuronal subtype diversification. FOXN4 is expressed in a subset of mitotic progenitors during retinogenesis. As such, FOXN4 controls the formation of amacrine and horizontal cells by activating the expression of the retinogenic factors MATH-3, Neuro D and PROX1. During spinal neurogenesis, the p2 progenitor domain gives rise to two intermingled distinct subtypes of interneurons, termed V2a and V2b. FOXN4 is coexpressed with the bHLH factor ASH1 (Mash1) in a subset of p2 progenitors. Functionality of FOXN4 affects ASH1 expression and regulates interneuronal formation accordingly. Over-expression of FOXN4 alone in spinal neural progenitors promotes the V2a fate at the expense of the V2b fate, whereas ASH1 suppresses both the V2a and V2b fates. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FOXN4 of human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-195 mapping at the N-terminus of FOXN4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-195 mapping at the N-terminus of FOXN4 of human origin |
| Entrez Gene | 121643 |
|---|
| Application Notes | recommended for detection of FOXN4 of human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
