| Product Name | Neurobeachin Antibody (K-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of Neurobeachin of human origin |
| Modification Notes | Neurobeachin, also known as NBEA, BCL8B or lysosomal-trafficking regulator 2 (LYST2), is a 2,946 amino acid A-kinase anchor protein that localizes to the cytoplasm and peripheral membrane, and belongs to the WD repeat neurobeachin family. By binding the type II regulatory subunits of protein kinase A (PKA), Neurobeachin is able to anchor PKA to the membrane or cytoskeletal and organelle-associated proteins. Neurobeachin is expressed predominantly in brain, with moderate levels found in thymus, prostate, spleen, ovary and testis. Lower levels have been found in kidney, heart, skeletal muscle, intestine and pancreas. Neurobeachin exists as two alternatively spliced isoforms and contains one BEACH domain and five WD repeats. Mutations of the gene encoding Neurobeachin is associated with idiopathic autism and is disrupted in patients with multiple myeloma. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Neurobeachin of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with isoforms 1 and 2: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of Neurobeachin of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of Neurobeachin of human origin |
| Entrez Gene | 26960 |
|---|
| Application Notes | recommended for detection of Neurobeachin of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with isoforms 1 and 2: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
