| Product Name | ALMS1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 2881-3180 mapping within an internal region of ALMS1 of human origin |
| Modification Notes | ALMS1 (Alström syndrome protein 1), or ALSS, is a widely expressed protein that localizes to centrosomes and the basal bodies of cilia. It consists of a putative leucine zipper, a tandem repeat domain and a stretch of 17 glutamine residues followed by 7 alanine residues near the N-terminal. Three ALMS1 isoforms exist due to splicing variation. The first isoform is the full length ALMS1. Isoform 2 lacks amino acids 4121-4167. The third isoform is only 3858 amino acids long and it contains an alternate sequence for amino acids 3850-3858. ALMS1 may play a role in intracellular transport, microtubule organization and basal body and cilia function. A mutation in the gene encoding ALMS1 results in the dysfunction of basal bodies and/or cilia. This dysfunction is suggested to be the cause of Alström syndrome, a rare autosomal-recessive condition. Symptoms include insulin resistance, type 2 diabetes and obesity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ALMS1 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 2881-3180 mapping within an internal region of ALMS1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 2881-3180 mapping within an internal region of ALMS1 of human origin |
| Entrez Gene | 7840 |
|---|
| Application Notes | recommended for detection of ALMS1 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
