| Modification Notes |
EVI5L (ecotropic viral integration site 5-like), also known as EVI5-like protein, is a 794 amino acid protein containing one Rab-GAP TBC domain. EVI5L acts as a GTPase-activating protein with broad specificity and has been found to have significant Rab 2A and Rab10 GAP activity. EVI5L contains two coiled coil regions, and is encoded by a gene mapping to human chromosome 19p13.2. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs). |