Application
Western blot analysis of ADAM1 expression in F9 whole cell lysate.| Product Name | ADAM1 Antibody (M-145) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-145 mapping at the C-terminus of ADAM1 of mouse origin |
| Modification Notes | Fertilin, also known as PH-30, is a sperm surface protein that is a member of the MDC (metalloprotease, disintigrin-like, cysteine-rich) family of proteins. This family is also known as the ADAM (a disintegrin and a metalloprotease domain) family of proteins because the members contain a metalloprotease and a disintegrin domain. Approximately 30 ADAM family members have been identified so far, and members of this family function as proteases and/or as cell adhesion molecules. Fertilin is a heterodimer of fertilin-å and fertilin-∫ subunits, which are also known as ADAM1 and ADAM2, respectively. Both subunits are synthesized in the testis as larger precursors. ADAM1 is proteolytically processed in the testis into the mature form, while ADAM2 undergoes final processing during the epididymal transit. ADAM1 is also expressed, to a much lesser extent, in the liver. Functional blocking of the disintegrin domains of both ADAM1 and ADAM2 inhibits sperm-egg binding, and recombinant forms of the extracellular domains of both subunits bind the surface of eggs. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ADAM1 of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-145 mapping at the C-terminus of ADAM1 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-145 mapping at the C-terminus of ADAM1 of mouse origin |
| Entrez Gene | 280668 |
|---|
Application
Western blot analysis of ADAM1 expression in F9 whole cell lysate.| Application Notes | recommended for detection of ADAM1 of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
