| Modification Notes |
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF168 (RING finger protein 168) is a 571 amino acid protein that contains one RING-type zinc finger. Via its RING-type zinc finger, RNF168 may play a role in transcriptional regulation and protein degradation events. The gene encoding RNF168 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. |