| Product Name | COL4A6 Antibody (M-137) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1323-1459 mapping near the C-terminus of COL4A6 of mouse origin |
| Modification Notes | Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. Collagens contain triple helix domains and frequently show lateral self-association in order to form complex connective tissues. Several collagens play a role in cell adhesion, which is important for maintaining normal tissue architecture and function. COL4A6 (collagen, type IV, alpha 6) is a 1,691 amino acid secreted protein belonging to the type IV collagen family. Type IV collagen, a major component of the basement membrane (BM), is composed of six genetically distinct alpha(IV) chains, alpha1(IV) to alpha6(IV). Defects in the gene encoding COL4A6 is believed is the cause of X-linked Alport syndrome (AS), which is characterized by macroscopic hematuria, cataracts and leiomyomatosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of COL4A6 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1323-1459 mapping near the C-terminus of COL4A6 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1323-1459 mapping near the C-terminus of COL4A6 of mouse origin |
| Application Notes | recommended for detection of COL4A6 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
