| Modification Notes |
IER5 (immediate early response 5), also known as SBBI48, is a 327 amino acid protein belonging to the immediate early response (IER) family of proteins. IER proteins are the first gene products to be induced during growth stimulation and/or arrest. Considered an early transcription factor, IER5 may be involved in mediating PSP (proteins and peptide bound polysaccharides)-induced apoptosis in HL-60 cells. PSP extracted from Basidiomycetous fungi are widely used in cancer immunotherapy and suggested to induce apoptosis in cancer cells in vitro. The gene encoding IER5 is located on human chromosome 1, which houses over 3,000 genes and is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. |