| Product Name | UTX/Y Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1102-1401 mapping at the C-terminus of UTX of human origin |
| Modification Notes | The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both vertebrates and invertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome) is a 1,401 amino acid nuclear protein that interacts with TLE1 (transducin-like enhancer of split 1) and, together, these proteins are thought to function as transcriptional repressors for a variety of targets. Expressed from a gene located on the inactive X chromosome, UTX functions as a histone demethylase that is involved in modulating the histone code (via demethylation of lysine residues on Histone H3) and in regulating Hox (homeobox) gene expression. UTX contains one JMJC domain and eight TPR repeats. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of UTX and UTY of mouse, rat, equine, canine, bovine and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1102-1401 mapping at the C-terminus of UTX of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1102-1401 mapping at the C-terminus of UTX of human origin |
| Entrez Gene | 7403 |
|---|
| Application Notes | recommended for detection of UTX and UTY of mouse, rat, equine, canine, bovine and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
