Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing nuclear staining of exocrine pancreas and islet cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Immunofluorescence staining of normal mouse intestine frozen section showing perinuclear staining.Application
Western blot analysis of Sox-11 protein expression in Y79 (A), SK-N-MC (B) and IMR-32 (C) nuclear extracts.| Product Name | Sox-11 Antibody (H-290) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 121-410 of Sox-11 of human origin |
| Modification Notes | The Sox family are comprised of members that are related to the mammalian sex determining gene SRY. The Sox family of genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been conserved during evolution and play key roles during animal development. Some are involved in human diseases, including sex reversal. Sox-11 (SRY (sex determining region Y)-box 11) is a 441 amino acid nuclear protein expressed mainly in the nervous system. Containing an HMG box DNA-binding domain, Sox-11 may play a critical role in the developing nervous system. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISAGSChIP |
| recommended for detection of Sox-11 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 121-410 of Sox-11 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 121-410 of Sox-11 of human origin |
| Entrez Gene | 6664 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing nuclear staining of exocrine pancreas and islet cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Immunofluorescence staining of normal mouse intestine frozen section showing perinuclear staining.
Application
Western blot analysis of Sox-11 protein expression in Y79 (A), SK-N-MC (B) and IMR-32 (C) nuclear extracts.| Application Notes | recommended for detection of Sox-11 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
