| Product Name | MGC33894 Antibody (N-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of MGC33894 of human origin |
| Modification Notes | MGC33894, also known as C17orf103 (chromosome 17 open reading frame 103) or GTLF3B, is a 113 amino acid protein that belongs to the GTLF3B family and is encoded by a gene that maps to human chromosome 17p11.2. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Gtlf3b of mouse origin, MGC33894 of human origin and the corresponding rat homolog by WB, IF and ELISA also reactive with additional species, including bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of MGC33894 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of MGC33894 of human origin |
| Entrez Gene | 256302 |
|---|
| Application Notes | recommended for detection of Gtlf3b of mouse origin, MGC33894 of human origin and the corresponding rat homolog by WB, IF and ELISA also reactive with additional species, including bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
