Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Immunofluorescence staining of normal mouse kidney frozen section showing cytoplasmic staining.| Product Name | folliculin Antibody (FL-342) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-342 representing full length folliculin isoform 2 of human origin |
| Modification Notes | Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant cancer syndrome characterized by kidney tumors, benign tumors of the hair follicle and spontaneous pneumothorax. BHD is also associated with neoplastic colonic polyps. The BHD gene maps to chromosome 17p11.2 and encodes the protein folliculin. Folliculin is widely expressed. Notably, folliculin is expressed in the kidney, lung and skin, where BHD tumors arise. Specifically, the (C)8 tract in exon 11 is a mutational hot spot in BHD. BHD appears to have reduced penetrance or late onset. In a study of the renal tumors in 30 BHD patients, preoperative computed tomography scans detect a mean of 5.3 tumors per patient with a range 1-28 tumors. Multiple and bilateral tumors appear at a mean of 50.7 years. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of folliculin isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-342 representing full length folliculin isoform 2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-342 representing full length folliculin isoform 2 of human origin |
| Entrez Gene | 201163 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Immunofluorescence staining of normal mouse kidney frozen section showing cytoplasmic staining.| Application Notes | recommended for detection of folliculin isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
