Application
Western blot analysis of GRHL3 expression in placenta tissue extract.| Product Name | GRHL3 Antibody (S-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against GRHL3 of human origin |
| Modification Notes | The grainyhead subfamily, whose members include GRHL1, GRHL2 and GRHL3, consist of orthologs of the Drosophila grainyhead (grh) gene. In Drosophila, grh is involved in early dorsal/ventral patterning and tissue development. The grainyhead subfamily members are, therefore, believed to act as transcription factors during development. GRHL1, GRHL2 and GRHL3 are localized to the nucleus and exist as homodimers or as heterodimers with each other. GRHL3, also known as sister of mammalian grainyhead (SOM) or transcription factor CP2-like 4 (TFCP2L4), is a 626 amino acid protein. Transgenic GRHL3-null mouse embryos have displayed many neural tube defects, indicating a significant role of GRHL3 in neural tube formation during development. GRHL3 is widely expressed and exists as 4 isoforms produced by alternative splicing. Isoform 2 has been shown to be prostate specific. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of GRHL3 of mouse and human origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against GRHL3 of human origin |
|---|---|
| Tissue Specificity | raised against GRHL3 of human origin |
| Entrez Gene | 57822 |
|---|
Application
Western blot analysis of GRHL3 expression in placenta tissue extract.| Application Notes | recommended for detection of GRHL3 of mouse and human origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
