Application
Western blot analysis of AKR1B10 expression in HISM whole cell lysate (A) and human stomach tissue extract (B).| Product Name | AKR1B10 Antibody (H-69) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 79-147 mapping within an internal region of AKR1B10 of human origin |
| Modification Notes | AKR1B10 (aldo-keto reductase family 1 member B10) is also known as aldose reductase-like-1 (ARL-1), small intestine reductase (SI reductase) or aldose reductase-related protein (ARP or hARP). AKR1B10 is found in many tissues but is predominantly expressed in small intestine, colon and adrenal gland. AKR1B10 is an efficient reductase for aliphatic and aromatic aldehydes. It plays a role in steroid metabolism as well as detoxification of aldehydes in digested food, and may be involved in the retinal-retinoic acid signaling pathway. AKR1B10 is prominently overexpressed in non-small cell lung carcinoma and adenocarcinoma. Cigarette smoking is an independent variable responsible for this overexpression. AKR1B10 may play a role regulating cell proliferation and cellular response to carbonyl stress. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of AKR1B10 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 79-147 mapping within an internal region of AKR1B10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 79-147 mapping within an internal region of AKR1B10 of human origin |
| Entrez Gene | 57016 |
|---|
Application
Western blot analysis of AKR1B10 expression in HISM whole cell lysate (A) and human stomach tissue extract (B).| Application Notes | recommended for detection of AKR1B10 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
