| Product Name | BRIDGE-1 Antibody (H-155) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 31-185 mapping within an internal region of BRIDGE-1 of human origin |
| Modification Notes | BRIDGE-1, a protein homologous to a previously cloned proteasome subunit p27 is important in regulating Insulin and other islet genes in the pancreas. BRIDGE-1 is highly expressed in pancreatic b-cells and is predominantly located in the nucleus, although lower levels are expressed in the cytoplasm. BRIDGE-1 contains a conserved PDZ-like domain that mediates protein-protein interactions in a variety of intracellular signaling processes, including the transactivational activity of E2A. One mechanism of the activation of gene transcription in pancreatic b-cells is the interaction of E2A with coactivating proteins such as CBP, p300 and BRIDGE-1. The interaction of E12 and E47, members of the E2A family of transcription factors, with the PDZ-domain of BRIDGE-1 suggest a novel mechanism for Insulin gene regulation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BRIDGE-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 31-185 mapping within an internal region of BRIDGE-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 31-185 mapping within an internal region of BRIDGE-1 of human origin |
| Entrez Gene | 5715 |
|---|
| Application Notes | recommended for detection of BRIDGE-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
