| Product Name | iASPP Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 107-395 mapping within an internal region of iASPP of human origin |
| Modification Notes | Apoptosis stimulating protein of p53 (ASPP) is a family of proteins that act as regulators of apoptosis via their interactions with p53. ASPP1 and ASPP2 are both members of the ASPP family that regulate p53 by enhancing its transactivation function and binding to proapoptotic genes. iASPP, is the third member of the ASPP family and is considered inhibitory as it negatively regulates p53. iASPP is the most evolutionarily conserved inhibitor of p53 induced apoptosis. Expression of iASPP is upregulated in human breast carcinomas that express wildtype p53. Overexpression of iASPP may play a role in leukemogenesis and progression of acute leukemia. Inhibiting iASPP may be an effective strategy for treating tumors expressing wildtype p53. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of iASPP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 107-395 mapping within an internal region of iASPP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 107-395 mapping within an internal region of iASPP of human origin |
| Entrez Gene | 10848 |
|---|
| Application Notes | recommended for detection of iASPP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
