| Modification Notes |
The solute carrier (SLC6) family, also known as the neurotransmitter transporter family, is one of the largest transporter families in the human genome comprising 20 members. The Sodium- and chloride-dependent transporter XTRP3, also designated neurotransmitter transporter rB21A homolog is expressed in the medullary layer of the brain, as well as in the kidney, lung, and small intestinal tissues. XTRP3 is a 616-amino acid membrane protein that contains 12 putative transmembrane domains and several glycosylation sites that may play a role in regulating cerebrospinal fluid (CSF) levels of its substrate. XTRP3 may be a candidate for transporter-based therapeutic agents aiding in neurological and psychiatric disorders. |