| Product Name | XAGE-1 Antibody (H-92) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-92 mapping at the N-terminus of XAGE-1 of human origin |
| Modification Notes | XAGE-1 is a cancer testis antigen with an expression pattern that is limited to germ cells of the testis and a variety of neoplastic tissues, but is abundantly expressed in breast, prostate and lung cancer, as well as in Ewing’s sarcomas and rhabdomyosarcomas. The XAGE-1 gene lies on the X chromosome and encodes for a 146 amino acid protein. XAGE-1 expression in normal and cancerous tissues is regulated by methylation of the CpG island in the gene promoter. Four transcript variants of XAGE-1 (XAGE-1a-d) exist, and XAGE-1b and XAGE-1d are specifically overexpressed in lung cancer. Because XAGE-1 is present in such a diverse range of cancers, it may be useful as a target for many cancer immunotherapies. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of all isoforms of XAGE-1 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-92 mapping at the N-terminus of XAGE-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-92 mapping at the N-terminus of XAGE-1 of human origin |
| Entrez Gene | 9503 |
|---|
| Application Notes | recommended for detection of all isoforms of XAGE-1 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
