| Product Name | DIXDC1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 121-420 mapping within an internal region of DIXDC1 of human origin |
| Modification Notes | DIXDC1 (DIX domain containing 1), also known as CCD1 or Dixin, is a 683 amino acid protein protein that localizes to the cell junction and to the cytoplasm in an isoform-dependent manner and contains one DIX domain and one CH (calponin-homology) domain. Expressed ubiquitously with highest expression in skeletal and cardiac muscle, DIXDC1 interacts with F-Actin and functions as a positive regulator of the Wnt signaling pathway, effectively targeting the ∫-catenin-TCF complex for gene expression and mediating Actin dynamics within the cytoskeleton. The gene encoding DIXDC1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DIXDC1 isoforms 1, 2, 3 and 4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 121-420 mapping within an internal region of DIXDC1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 121-420 mapping within an internal region of DIXDC1 of human origin |
| Entrez Gene | 85458 |
|---|
| Application Notes | recommended for detection of DIXDC1 isoforms 1, 2, 3 and 4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
