| Product Name | ILPIP Antibody (H-80) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 277-356 mapping near the C-terminus of ILPIP of human origin |
| Modification Notes | ILPIP (ILP-interacting protein), also designated amyotrophic lateral sclerosis 2 juvenile chromosome region gene 2 (ALS2CR2), interacts with X-linked IAP (XIAP), a member of the inhibitor of apoptosis protein (IAP) family. The IAP family are caspase inhibitors that block the execution phase of apoptosis. IAPs are involved in the development and progression of solid tumors and hematologic malignancies, making them a potential target for cancer therapeutics. ILPIP enhances XIAP-mediated activation of the TGF∫-activated kinase 1/c-Jun NH2-terminal kinase 1 (TAK1/JNK1) signal transduction pathway. This pathway protects against the interleukin-1b converting enzyme of FAS-mediated apoptosis. The protection of XIAP against apoptosis by ILPIP is caspase-independent. When expressed alone, ILPIP only moderately activates the TAK1/JNK1 signal transduction pathway. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ILPIP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 277-356 mapping near the C-terminus of ILPIP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 277-356 mapping near the C-terminus of ILPIP of human origin |
| Application Notes | recommended for detection of ILPIP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
