| Modification Notes |
SUT-1 (sulphate transporter 1), also known as Na(+)/sulfate cotransporter SUT-1 or SLC13A4 (solute carrier family 13 member 4), is a 626 amino acid multi-pass membrane protein that belongs to the SLC13A transporter family and the NADC subfamily. While highly expressed in placenta and testis, SUT-1 is expressed at lower levels in brain, heart, thymus and liver. SUT-1 functions as a sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV). The gene that encodes SUT-1 contains 46,968 bases and maps to human chromosome 7q33. Housing over 1,000 genes, chromosome 7 comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. |