Application
Western blot analysis of Aspartoacylase expression in non-transfected: (A) and human Aspartoacylase transfected: (B) 293T whole cell lysates.Application
Western blot analysis of Aspartoacylase expression in non-transfected: (A) and mouse Aspartoacylase transfected: (B) 293T whole cell lysates.Application
Western blot analysis of Aspartoacylase expression in non-transfected: (A) and human Aspartoacylase transfected: (B) 293T whole cell lysates.| Product Name | Aspartoacylase Antibody (H-93) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 188-279 mapping within an internal region of Aspartoacylase of human origin |
| Modification Notes | Aspartoacylase, also known as ASPA, ACY2 or ASP, is a 313 amino acid protein that is expressed in liver, lung and kidney tissue, as well as in skeletal muscle and in cerebral white matter. Existing as a homodimer, Aspartoacylase functions to catalyze the deacetylation of N-acetylaspartic acid (NAA) (a protein whose hydrolysis is crucial to maintenance of intact white matter) to produce acetate and L-aspartate. Defects in the gene encoding Aspartoacylase are the cause of Canavan disease (CAND), which is a rare neurodegenerative condition that is characterized by white matter vacuolization and demeylination, resulting in a spongy deterioration of brain tissue. CAND is generally characterized by atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental retardation, megalocephaly and death. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Aspartoacylase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 188-279 mapping within an internal region of Aspartoacylase of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 188-279 mapping within an internal region of Aspartoacylase of human origin |
| Entrez Gene | 443 |
|---|
Application
Western blot analysis of Aspartoacylase expression in non-transfected: (A) and human Aspartoacylase transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of Aspartoacylase expression in non-transfected: (A) and mouse Aspartoacylase transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of Aspartoacylase expression in non-transfected: (A) and human Aspartoacylase transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of Aspartoacylase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
