| Modification Notes |
CTP (citrate transport protein), also known as Tricarboxylate transport protein, SLC25A1 or SLC20A3, is a 311 amino acid mitochondrial multi-pass membrane protein that primarily functions to transport citrate across the mitochondrial inner membrane. Since it provides a carbon source for sterol and fatty acid biosynthesis, CTP is important for the bioenergetics of hepatic cells. The gene encoding CTP resides within a chromosomal region that is frequently deleted in patients that suffer from DiGeorge syndrome, a disease characterized by susceptibility to infection due to a deficit of T cells, cardiac malformations and tetany or seizures. Playing a significant role in intermediate metabolism, it appears that CTP function may be altered in type I diabetes and some cancers. CTP is highly expressed in adult ovary, gut liver, and testis, as well as in fetal kidney, lung, brain and liver. |