| Product Name | TGIF2 Antibody (H-64) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 115-178 mapping within an internal region of TGIF2 of human origin |
| Modification Notes | TGIF2 (TGF∫-induced factor homeobox 2), also called 5’-TG-3’-interacting factor 2, is a widely expressed protein with predominant expression in kidney, heart and testis, and it belongs to the TALE/TGIF homeobox family. Localizing to the nucleus, TGIF2 contains one homeobox DNA-binding domain and is believed to function as a transcriptional repressor. Similar to the closely related protein TGIF, TGIF2 recruits histone deacetylases (HDACs) to TGF∫-responsive genes, thereby mediating their transcriptional repression. Specifically, TGIF2 interacts with HDAC1 and the transcriptional modulator Smad3. Mutations in the gene encoding TGIF2 can result in holoprosencephaly, a disorder characterized by the underdevelopment of the prosencephalon. In addition, TGIF2 is overexpressed in some ovarian cancers, suggesting a possible role of TGIF2 in carcinogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TGIF2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 115-178 mapping within an internal region of TGIF2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 115-178 mapping within an internal region of TGIF2 of human origin |
| Entrez Gene | 60436 |
|---|
| Application Notes | recommended for detection of TGIF2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
