| Product Name | COX10 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of COX10 of human origin |
| Modification Notes | Cytochrome c oxidase (COX) localizes to the mitochondrial inner membrane and is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient with chemical energy from the reduction of O2. The COX subunit 10 or COX10 (also known as heme A: farnesyltransferase or Heme O synthase) is a multi-pass transmembrane protein encoded by a nuclear gene. COX10 was originally identified in yeast and its structure is conserved from E. coli to human. COX10 is responsible for catalyzing the first step in the biosynthesis of heme A: the conversion of protoheme (heme B) to heme O by the addition of a farnesyl group. As a result, COX10 is necessary for the expression of a functional COX. A mutation in the gene encoding COX10 may result in COX deficiency in humans. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of COX10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of COX10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of COX10 of human origin |
| Entrez Gene | 1352 |
|---|
| Application Notes | recommended for detection of COX10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
