| Modification Notes |
Vacuolar sorting proteins (VPSs) are required for proper trafficking of endocytic and biosynthetic proteins to the vacuole and play an important role in the budding process of cells. VPS37A (vacuolar protein sorting 37 homolog A), also known as HCRP1 or PQBP2, is a 397 amino acid protein that contains one VPS37 C-terminal domain and localizes to the nucleus, as well as to the peripheral membrane and the late endosome membrane. Expressed in a variety of tissues with higher levels in liver, VPS37A functions as a component of the multi-protein ESCRT-I (endosomal sorting complex required for transport I) complex and plays a role in vesicular trafficking and protein sorting, as well as cell growth and differentiation. Multiple isoforms of VPS37A exist due to alternative splicing events. |