| Modification Notes |
The Adiponutrin family consists of Adiponutrin (ADPN), adipocyte triglyceride lipase (ATGL, also designated Desnutrin), GS1, GS2, GS2-like and PNPLA1. ADPN, ATGL and GS2 display lipase activity, which is dependent upon the presence of an activated serine residue. GS1, also designated DXF68S1E or haloacid dehalogenase-like hydrolase domain containing 1A (HDHD1A), is a 214-amino acid protein that is detected in human placenta and fibroblasts. The gene which encodes for GS1, HDHD1A, is of interest because it is an X-linked gene that escapes X-inactivation. This characteristic of the HDHD1A gene is particularly important in the understanding of human X chromosome structural organization as well as the mechanism of X-inactivation. |