Application
Western blot analysis of KPI-2 expression in non-transfected (A) and human KPI-2 transfected (B) 293 whole cell lysates.| Product Name | KPI-2 Antibody (D-25) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of KPI-2 of human origin by WB, IP and ELISA |
| Modification Notes | KPI-2 (kinase/phosphatase/inhibitor 2), also known as BREK, LMR2, cprk, AATYK2 or LMTK2 (lemur tyrosine kinase 2), is a 1,503 amino acid single-pass membrane protein belonging to the protein kinase superfamily and the protein tyrosine kinase family. Mainly expressed in skeletal muscle, and weakly in brain and pancreas, KPI-2 contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. KPI-2 may be involved in nerve growth factor (NGF)-TrkA signaling, endosomal membrane trafficking and spermatogenesis. KPI-2 localizes to cytoplasmic membrane vesicles and to perinuclear recycling endosomes. KPI-2 is critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes. The gene encoding KPI-2 is a potential therapeutic target for prostate cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of KPI-2 of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of KPI-2 of human origin by WB, IP and ELISA |
| Entrez Gene | 22853 |
|---|
Application
Western blot analysis of KPI-2 expression in non-transfected (A) and human KPI-2 transfected (B) 293 whole cell lysates.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
