Application
Western blot analysis of GNB1L expression in Jurkat whole cell lysate.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skin tissue showing cytoplasmic localization.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.Application
Western blot analysis of GNB1L expression in K-562 whole cell lysate.| Product Name | GNB1L Antibody (Q-25) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of GNB1L of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA |
| Modification Notes | WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. GNB1L (guanine nucleotide binding protein (G protein), beta polypeptide 1-like), also known as FKSG1, GY2, KIAA1645 or WDR14, is a 327 amino acid protein that exists as two alternatively spliced isoforms and contains six WD repeats. Expressed ubiquitously with highest levels present in spleen, liver, heart, kidney, pancreas and skeletal muscle, GNB1L is thought to play a role in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder that is the result of a deletion on chromosome 22 and is associated with a variety of facial anomalies and cardiac malformations. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| WB:1:500~1:2000 IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of GNB1L of mouse rat and human origin by WB IP IF IHC(P) and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of GNB1L of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA |
| Entrez Gene | 54584 |
|---|
Application
Western blot analysis of GNB1L expression in Jurkat whole cell lysate.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skin tissue showing cytoplasmic localization.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.
Application
Western blot analysis of GNB1L expression in K-562 whole cell lysate.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
